Spain  VALLADOLID 03/03/2021

Hydrogel injection may change the way the heart muscle heals after a heart attack

The regeneration of cardiac tissue is minimal so that the damage caused cannot be repaired by itself

Researchers at CÚRAM, the SFI Research Centre for Medical Devices based at National University of Ireland Galway, and BIOFORGE Lab, at the University of Valladolid in Spain, have developed an injectable hydrogel that could help repair and prevent further damage to the heart muscle after a heart attack.

 

 
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Portugal  PORTUGAL 10/02/2021

Sepsis: new evidence to understand and fight the disease

Study published in the journal Cell Host & Microbe reveals new mechanisms that confer resistance against sepsis and sheds light on key aspects of hominid evolution

Researchers discover that the loss of a specific molecule may explain how primates evolved to be able to resist to bacterial infections leading to sepsis. The study published in the prestigious scientific journal Cell Host & Microbe reveals that, in mice, the absence of this molecule (the α-Gal glycan) from the antibodies structure increases the ability to the same antibody to kill bacteria. This evolutionary advantage emerged with a cost, the reproductive decline. These findings shed light on key aspects of hominid evolution and reveal new mechanisms that confer resistance against sepsis, crucial to understand and fight the disease.

 
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Spain  MADRID 18/01/2021

A mathematical study describes how metastasis starts

Research by the UC3M and UCM

A scientific study carried out by the Universidad Carlos III de Madrid (UC3M) and the Universidad Complutense de Madrid (UCM) has produced a mathematical description of the way in which a tumor invades the epithelial cells and automatically quantifies the progression of the tumor and the remaining cell islands after its progression. The model developed by these researchers could be used to better understand the biophysical characteristics of the cells involved when developing new treatments for wound healing, organ regeneration, or cancer progression.

 
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Portugal  PORTUGAL 17/12/2020

A matter of balance: asymmetric divisions are crucial to form a functional retina

Study published in the scientific journal 'eLife' opens new paths for understanding how the complex brain develops its architecture and function

Researchers at the Instituto Gulbenkian de Ciência and the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden, Germany, have discovered that in the developing retina, and important part of the central nervous system, the divisions leading to the first differentiating neurons are asymmetric and that this asymmetry is necessary to generate the correct types of neurons in the right numbers and proportions. The study, published in the scientific journal eLife, is the first to report this asymmetry and the molecular processes underlying it, opening new paths for understanding how the complex brain develops its architecture and function.

 
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Brazil  BRASIL 20/10/2020

Immunity induced by other coronaviruses may not protect older people against COVID-19

Study led by researchers at Oxford University suggests that after successive infections by the coronaviruses that cause common colds throughout life the defense system becomes specialized and cannot recognize emergent varieties such as SARS-CoV-2

An international research group led by scientists at the University of Oxford in the United Kingdom have developed a mathematical model that may explain why children are less susceptible to COVID-19 while older people frequently become critically ill when infected by the novel coronavirus.

 
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Portugal  PORTUGAL 15/10/2020

New tricks for old antibiotics

Researchers uncovered that a group of antibiotics confers protection against sepsis, beyond their ability to directly control the infection

The study led by Luís Ferreira Moita, principal investigator at Instituto Gulbenkian de Ciência, and published in the journal Immunity, reveals that tetracyclines (broad spectre antibiotics), by partially inhibiting cell mitochondria activity, induce a compensatory response on the organism that decreases tissue damage caused during infection. This finding opens new doors in the field of disease tolerance and positions this group of antibiotics as potential adjuvant treatment for sepsis, due to their effects that go beyond the control of bacterial burden.

 
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Brazil  BRASIL 03/08/2020
#CovidNewsDiCYT

Adipose tissue may be a reservoir for SARS-CoV-2, Brazilian researchers suggest

A study showed that the novel coronavirus can infect human adipocytes and that the viral load is three times higher in aged adipose cells

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Portugal  AVEIRO 03/07/2020

Smell can play an important role in Autism

Published this month in Neuroscience & Biobehavioral Reviews, the work highlights the potential of olfaction as a facilitator and privileged entry point for socio-emotional information in the population with ASD

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Portugal  PORTUGAL 24/06/2020

Hormone involved in obesity is a risk factor for sepsis

A group of scientists from Instituto Gulbenkian de Ciência (IGC) discovered that a hormone that has been pointed out as a treatment for obesity is a risk factor for sepsis

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Spain  MADRID 01/06/2020
#CovidNewsDiCYT

A geospatial analysis identifies the areas most vulnerable to COVID-19

A report identifies the areas in Spain that require increased measures of protection against new outbreaks of the COVID19 epidemics

A report based on a geospatial analysis conducted by researchers from the Universidad Carlos III de Madrid (UC3M) in collaboration with TAPTAP Digital, using additional data from Predicio and Tamoco, identifies the areas in Spain that require increased measures of protection against new outbreaks of the COVID19 epidemics.

 
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Spain  MADRID 29/05/2020

Research into new treatments for rare genetic diseases

Collaboration between UC3M, Almirall and Fundación MEDINA

The University Carlos III Madrid (UC3M), Almirall, S.A. (ALM) and the MEDINA Foundation have launched a project to find new treatments for recessive dystrophic epidermolysis bullosa and other genetic diseases caused by nonsense mutations. The project is partially-funded by the Spanish Ministry of Science and Innovation’s Center for Industrial and Technological Development (CDTI).

 
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Brazil  BRASIL 13/05/2020

Platelets exacerbate immune response

Clotting cells are also an important regulator of inflammation, reveals study

Platelets not only play a key role in blood clotting, but can also significantly intensify inflammatory processes. This is shown by a new study carried out by scientists from the University of Bonn together with colleagues from Sao Paulo (Brazil). In the medium term, the results could open up new ways to treat autoimmune diseases. They have now been published in the renowned journal Cell Reports.

 
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Spain  MADRID 27/04/2020

How to get the most out of the tests

Article written by Ander Galisteo, predoctoral researcher at the IMDEA Networks Institute and the University Carlos III of Madrid (UC3M)

With Covid-19 hitting all areas of our lives, there is a need both socially and politically to know what the state of the citizenry is. We need to know how Covid-19 is evolving, how many citizens have it, how and where they are infected, what is the probability of them getting sick, etc. All these data are necessary in order to take appropriate measures and to know when and how we are going to recover certain areas of our lives and what other aspects are going to change forever.

 
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Mexico  MÉXICO 07/04/2020

Indigenous American ancestry may be associated with HER2-positive breast cancer

According to a study published in 'Cancer Research'

An increased proportion of Indigenous American (IA) ancestry was associated with a greater incidence of HER2-positive breast cancer, according to a study published in Cancer Research, a journal of the American Association for Cancer Research.

 
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Spain  ESPAÑA 03/04/2020

Researchers develop a computer simulator that recreates the spread of COVID-19 in Europe

Based on parameters such as climate, social distancing policies and transportation

A team of Spanish researchers have designed and validated a simulator to enable study of the evolution of the COVID-19 illness in Spain and in all Europe, based on parameters such as climate, social distancing policies and transportation. This research work has been carried out by scientists and technologists from Universidad Carlos III de Madrid (UC3M), the Centro Nacional de Epidemiología (CNE) and the Consorcio Centro de Investigación Biomédica en Red (CIBER) from the Instituto de Salud Carlos III (ISCIII), in conjunction with the Barcelona Supercomputing Center - Centro Nacional de Supercomputación (BSC-CNS).

 
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Spain  MADRID 25/03/2020

The effectiveness of social distancing strategies in the face of an epidemic has been analysed

An international study based on census and real-world mobility flow

The complete isolation of the population in the face of an epidemic such as COVID-19 is a strategy that requires subsequently adopting active measures in order to maximise its effectiveness, such as conducting large scale diagnostic tests, isolating people with symptoms and identifying those with whom they have had contact. This is one of the main conclusions from a study conducted by a team of researchers from the Universidad Carlos III de Madrid (UC3M), the University of Zaragoza, the Massachusetts Institute of Technology (MIT) and the ISI Foundation in Italy.

 
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Spain  MADRID 29/01/2020

An international scientific consortium is launched to accelerate the development of comprehensive treatments against tuberculosis

The UC3M is coordinating the ERA4TB project, composed of more than 30 partners from 13 countries

Accelerating the development of antibiotics against all forms of tuberculosis is the objective of ERA4TB (European Regimen Accelerator for Tuberculosis), one of the largest European scientific projects in this area of research. This consortium, which includes a significant number of Spanish researchers, is being coordinated by the Universidad Carlos III de Madrid (UC3M), led by GlaxoSmithKline Spain and is under the scientific management of the Pasteur Institute. With a team of more than thirty public and private organisations and a budget over 200 million euro, ERA4TB aims to radically transform the way in which new therapies are developed for the treatment of tuberculosis.

 
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Brazil  SãO PAULO 30/12/2019

Novel genetic signature that can predict some kinds of breast cancer is identified

The discovery also contributes to a better understanding of the molecular mechanisms of pathological angiogenesis, the aberrant proliferation of blood vessels that occurs during cancer and other diseases

Researchers have identified a genetic signature with prognostic value for certain kinds of breast cancer. The discovery also contributes to a better understanding of the molecular mechanisms of pathological angiogenesis, the aberrant proliferation of blood vessels that occurs during cancer and other diseases.

 
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Brazil  BRASIL 07/10/2019

Compounds extracted from Cerrado plant combat fungus that causes candidiasis

Four substances isolated from Mimosa caesalpiniifolia were found to be more effective against thrush and candida than was fluconazole, the drug usually prescribed to treat the disease. Brazilian researchers are developing an ointment

Fungi of the genus Candida cause thrush and candidiasis, a fairly common disease in humans. It can be lethal to individuals with low immunity, especially when they are hospitalized. Although the drug most widely used to combat the disease is effective in most cases, some varieties of the fungus are drug-resistant.

 
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Spain  MADRID 11/09/2019

Olfactory and auditory stimuli change the perception of our body

New knowledge in the field of cognitive neuroscience and human-computer interaction

A pioneering investigation developed by the Universidad Carlos III de Madrid (UC3M) alongside the University of Sussex and University College London, shows that olfactory stimuli combined with auditory stimuli can change our perception of our body. These results provide new knowledge in the field of cognitive neuroscience and human-computer interaction.

 
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